Skp2 Regulates Myc Protein Stability and Activity
نویسندگان
چکیده
منابع مشابه
The tumor suppressor protein HBP1 is a novel c-myc-binding protein that negatively regulates c-myc transcriptional activity.
c-Myc is an important transcription factor that regulates cellular proliferation, cell growth, and differentiation. A number of transcriptional co-factors for c-Myc have been described that have binding sites within highly conserved regions of the c-Myc transactivational domain (TAD). Given the importance of the c-Myc TAD, we set out to identify new proteins that interact with this region using...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2003
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(03)00173-4